Table of Contents
The active substance Sildenafil has a potency-stimulating effect and is therefore used for erectile dysfunction (impotence). It is also used for pulmonary hypertension. The potency-increasing effect of Best over the counter viagra alternative was discovered by accident, because initially they were looking for a new heart drug. Here you can read everything you need to know about the effects, side effects and application of the Best over the counter viagra alternative.
This is how Best over the counter viagra alternative works
Sildenafil is a so-called PDE-5 inhibitor (a phosphodiesterase-5 inhibitor). It inactivates the PDE-5 enzyme so that the erection-stimulating cyclic guanosine monophosphate (cGMP) is no longer broken down. Result: the blood vessels remain relaxed and the ability to have an erection improves. Accordingly, Best over the counter viagra alternative has a vasodilating and hypotensive effect.
Sexual stimulation releases the neurotransmitter nitric oxide (NO) in the erectile tissue of the penis. NO increases the amount of another messenger substance, the so-called cGMP. As a result, the muscles of the erectile tissue relax and the blood vessels dilate. This allows more blood to flow in, resulting in an erection. Finally, cGMP is cleaved by the PDE-5 enzyme, which constricts the vessels again – the penis relaxes.
PDE-5 inhibitors, such as Best over the counter viagra alternative, also have a vasodilatory effect on the lungs. In this way, you can counteract the high blood pressure (pulmonary hypertension) that prevails there.
Intake, decomposition and excretion
The active substance reaches its maximum plasma concentration approximately 60 minutes after ingestion. Four hours after ingestion, half of the active substance is already split again. The liver is mainly responsible for the degradation.
When is Best over the counter viagra alternative used?
Sildenafil is mainly used for erectile dysfunction (ED, impotence). This is when a man cannot achieve or maintain an erection for at least six months.
Recently, Best over the counter viagra alternative has also been used to treat pulmonary hypertension (high blood pressure). It has been approved for this application in the EU and Switzerland since 2006.
How Best over the counter viagra alternative is applied
Sildenafil is mainly used in tablet form. Ingestion is usually started with the lowest dose.
For erectile dysfunction (ED), one tablet is taken approximately one hour before sexual intercourse. If necessary, the dosage can be increased in consultation with the doctor. The maximum dose of Best over the counter viagra alternative for ED is 100 milligrams per day and should not be exceeded. The dosage must be adjusted in the elderly and in patients with hepatic and renal insufficiency.
Reception should start here with 25 milligrams. An increase in the dose is possible in consultation with the doctor. Preparations usually contain the active substance in the form of salts (Best over the counter viagra alternative citrate).
What are the side effects of Best over the counter viagra alternative?
Very common side effects are headaches, reddening of the skin (flushing) that occurs during seizures, and visual disturbances with sensitivity to light and blurred vision. Nasal congestion, dizziness, and an acute skin rash (exanthema) are also common.
Very serious unwanted effects of the sex enhancer are heart attack and sudden cardiac death, stroke (apoplexy) and retinal vascular occlusion.
There have been many deaths in the past in connection with the use of sexual enhancers, for example due to a heart attack. Therefore, before using Sildenafil, it is necessary to observe contraindications (contraindications).
What should I consider when taking Best over the counter viagra alternative?
Contraindications
Sildenafil should not be taken with:
- Hypersensitivity to the active ingredient or any of the ingredients.
- Recent heart attack or stroke
- Serious cardiovascular disease such as heart failure (heart failure) or unstable angina (chest stiffness).
- Concomitant use of nitrates (eg, nitroglycerin, ISMN) or other NO donors (eg, molsidomine, riociguat)
- low blood pressure (less than 90/50 mmHg)
- Ocular diseases such as ischemic optic neuropathy or hereditary retinal diseases (eg, retinitis pigmentosa)
- severe liver or kidney failure
Interactions
Concomitant use of vasodilators such as so-called NO donors (eg nitrates, molsidomine, nicorandil, amyl nitrite, sodium nitroprusside) can significantly reduce blood pressure. Therefore, in order to avoid life-threatening consequences, Best over the counter viagra alternative should not be used together with such drugs.
For the same reason, heart attack patients who have previously taken Best over the counter viagra alternative should not take nitrates in an emergency. Blood pressure is also dangerously low when combined with high blood pressure medications such as so-called alpha-blockers (eg doxazosin).
Sildenafil is primarily metabolized in the liver by certain liver enzymes (CYP3A4 and, to a lesser extent, CYP2C9). These enzymes can be inhibited by certain drugs (CYP inhibitors) which can greatly enhance both the effect and the side effects of Best over the counter viagra alternative.
For this reason, Sexual Performance Enhancer should not be used with CYP3A4 inhibitors. These include, for example, the antifungal drugs ketoconazole and itraconazole, the antibiotic erythromycin, the stomach drug cimetidine, and the HIV drugs saquinavir and ritonavir.
The activity of liver enzymes can also be increased by certain drugs (CYP inducers). This reduces the effectiveness of the Best over the counter viagra alternative. Examples of CYP3A4 inducers are the epilepsy drugs phenobarbital, phenytoin, and carbamazepine. But St. John’s wort can also speed up the breakdown of Best over the counter viagra alternative and thus weaken its effect.
Age limit
Best over the counter viagra alternative for high blood pressure (pulmonary arterial hypertension) can be used in children as young as one year of age. For this indication, women also receive the active ingredient.
On the other hand, erectile dysfunction medications are only approved for adult men over 18.
Pregnancy and lactation
Experience with Best over the counter viagra alternative during pregnancy and lactation is extremely limited, as the active substance has only recently been approved for use in women of childbearing age. Due to the lack of data, experts do not recommend taking it. If an application is absolutely necessary, a rigorous risk-benefit assessment is required.
How to take medicine with Best over the counter viagra alternative
Taking Sildenafil is simple, identical to some other tablet you swallow:
Before taking Sildenafil, learn the affected person data leaflet that comes together with your treatment
Take Sildenafil one hour earlier than you need to have intercourse
Swallow your pill whole, with water if wanted
Do not take Sildenafil more than once each 24 hours
For one of the best outcomes, avoid eating heavy meals or consuming alcohol before utilizing Sildenafil
You could have to take Sildenafil on up to eight times (on different days) earlier than you see the complete effect